Featured Research

image Comparing retrospective informant assessments to prospectively collected cognitive measures in the Health and Retirement Study

Using generalized estimating equations, Dr. Hamedani's team compared informant-reported change in memory and daily functioning to prospectively collected delayed word recall and instrumental activities of daily living (iADL) in the 10 years preceding Harmonized Cognitive Assessment Protocol (HCAP). Read more.

 Ali G Hamedani, Dylan Thibault, Katya Rascovsky, Allison W Willis, Kenneth M Langa
image Predictors of successful initiation of buprenorphine in enriched enrollment randomized withdrawal clinical trials in both opioid experienced and naïve participants: a participant-level meta-analysis

No prediction models exist for the success for buprenorphine initiation in opioid-naïve patients or in transition from other opioids in patients treated for chronic pain. Drs Farrar and Bilker and their team set out to create such a prediction model. Read more.

 Andrew Conroy, Warren B Bilker, Christopher J Miller, Charles E Argoff, Russell Bell, Jennifer Haythornthwaite, Jennifer S Gewandter, Ian Gilron, Katherine N Theken, John T Farrar
image Effect of exogenous testosterone on cardiovascular, cerebrovascular, and thromboembolic adverse events: Results of three complementary research designs

Researchers from a recent study involving two CCEB Senior Scholars compared the effects to glaucoma treatments, which served as an active neutral comparator. Read more.

 Tat-Thang Vo, Samrat Roy, Ting Ye, Askhan Erterfaie, Thanh Phuong Pham Nguyen, James Flory, Charles E Leonard, Dylan S Small, Sean Hennessey
image Challenging the Continued Usefulness of Social Media Recruitment for Surveys of Hidden Populations of People Who Use Opioids

In this viewpoint paper, we assessed social media recruitment for people who use opioids and described challenges and potential solutions for effective recruitment.

 Elizabeth D Nesoff, MPH, PhD ; Joseph J Palamar, PhD ; Qingyue Li, MSSP ; Wenqian Li, MSSP ; Silvia S Martins, MD, PhD.
image Association of Race and Ethnicity With Healthcare Utilization for Inflammatory Bowel Disease in the United States: A Retrospective Cohort Study

CCEB Senior Scholars collaborated with other experts in a recent study to evaluate the variations in healthcare for IBD patients by race and ethnicity. Read more.

 Abraham Segura, Colleen Brensinger, Virginia Pate, Shazia M Siddique, Lauren Parlett, Andres Hurtado-Lorenzo, Michael David Kappelman, James D Lewis
image Development of the Lee Symptom Scale-Skin Sclerosis for chronic GVHD-associated sclerosis

As Dr. Emily Baumrin noticed, patient voices have been absent in the measurement of skin sclerosis from chronic graft-versus-host disease (cGVHD) and how it severely impacts quality of life. Read more.

 Emily Baumrin, Joseph Pidala, Sandra A Mitchell, Lynn Onstad, Stephanie J Lee
image Lower Child Opportunity Index is associated with increased health care utilization following pediatric liver transplantation

To elucidate the relationship between social determinants of health and health care utilization among children (<18 y old at the time of LT) who have undergone LT, Dr Bittermann and her team performed a retrospective study merging data from the Organ Procurement and Transplantation Network (OPTN) and the Pediatric Health Information System (PHIS) database. Read more.

 Bennett, Aaron D.; Morales, Knashawn H.; Huang, Yuan-Shung V.; Tam, Vicky; Shah, Amit; Loomes, Kathleen M.; Serper, Marina; Bittermann, Therese
image Text Message System for the Prediction of Colonoscopy Bowel Preparation Adequacy Before Colonoscopy: An Artificial Intelligence Image Classification Algorithm Based on Images of Stool Output

Experts within Penn Medicine and the CCEB formed a team to develop an artificial intelligence (AI) machine-learning algorithm to detect if colonoscopy bowel preparation was complete by analyzing photos of stool sent via text messages from patients.

 Chethan Ramprasad, Divya Saini, Henry Del Carmen, Lev Krasnovsky, Rajat Chandra, Ryan Mcgregor, Russell T Shinohara, Eric Eaton, Meghna Gummadi, Shivan Mehta, James D Lewis
image The Adolescent Suicide Prevention in Routine clinical Encounters (ASPIRE) trial

Dr. Kristin Linn was awarded a methodological supplement to an ongoing R01 led by Dr. Rinad Beidas at Northwestern University.
image Race, Ethnicity, and Other Patient and Clinical Encounter Characteristics Associated with Patient Experiences of Access to Care

To assess current progress, a team of Penn Medicine faculty studied the relationship between patient experiences within the University of Pennsylvania Health System (UPHS) and race, ethnicity, and other sociodemographic characteristics. Read more.

 Jeromy W Gotschall, Robert Fitzsimmons, Daniel B Shin, Junko Takeshita
Abstract figure Real-World Effectiveness of BNT162b2 Against Infection and Severe Diseases in Children and Adolescents

Using electronic health record data from a national collaboration of pediatric health systems, this study examined the effectiveness of BNT162b2 vaccines for preventing COVID-19 infections and severe disease among previously uninfected children and adolescents.

 Qiong Wu, PhD*; Jiayi Tong, MS*; Bingyu Zhang, MS; Dazheng Zhang, MS; Jiajie Chen, PhD; Yuqing Lei, MS; Yiwen Lu, BS; Yudong Wang, PhD; Lu Li, BA; Yishan Shen, MS; Jie Xu, PhD; L. Charles Bailey, MD, PhD; Jiang Bian, PhD; Dimitri A. Christakis, MD, MPH; Megan L. Fitzgerald, PhD; Kathryn Hirabayashi, MPH; Ravi Jhaveri, MD; Alka Khaitan, MD; Tianchen Lyu, MS; Suchitra Rao, MBBS, MSCS; Hanieh Razzaghi, PhD, MPH; Hayden T. Schwenk, MD, MPH; Fei Wang, PhD; Margot I. Gage Witvliet, PhD; Eric J. Tchetgen Tchetgen, PhD; Jeffrey S. Morris, PhD; Christopher B. Forrest, MD, PhD; and Yong Chen, PhD.